| Composition |
Losartan Potassium 50 mg + Hydrochlorthiazide -12.5 mg tabs. |
| Indications |
- Essential hypertension
- Hypertension with concomitant diabetes
- Diabetic Nephropathy
|
| Dosage |
2 tablets 3 times daily for 4-5 days of heavy menstrual blood loss with pain. |
| Mechanism of Action |
Losartan and its metabolite block the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor. Hydrochlorothiazide, a thiazide diuretic affects the renal tabular mechanisms of electrolyte re-absorption, directly increasing excretion of sodium salt and chloride in approximately equivalent amounts. |
| Side effects |
COMMON
- Cardiovascular: Edema , Palpitations
- Dermatologic: Rash
- Endocrine metabolic: Electrolyte imbalance
- Gastrointestinal: Abdominal pain, Diarrhea, Nausea
- Musculoskeletal: Backache
- Neurologic: Asthenia, Dizziness, Headache
- Respiratory: Bronchitis, Cough, Pharyngitis, Sinusitis, Upper respiratory infection
- Other: Fatigue
SERIOUS
- Hepatic: Hepatitis (rare)
|
| Drug interactions |
- Angioedema (associated with aspirin and/or penicillin allergy)
- Avoid lithium
- Biliary cirrhosis or biliary obstruction
- Hyperuricemia or gout
- Hypotension, intravascular volume- and salt-depleted
- Liver disease
- May aggravate digitalis toxicity
- Renal artery stenosis; solitary kidney
- Hepatic or renal impairment
- Systemic lupus erythematosus
|
| Contraindications |
Tranexamic acid is contraindicated in patients with active intravascular clotting process, acquired defective color vision, subarachanoid hemorrhage, severe renal insufficiency and hypersensitivity to tranexamic acid.
Mefenamic acid is contraindicated: in patients with hypersensitivity to mefenamic acid, patients who have experienced asthma, urticaria, or allergic reaction after taking aspirin or other NSAID. |
| Contraindications |
- Anuria
- Hypersensitivity to hydrochlorothiazide, losartan, or sulfonamides
|
| Pregnancy/ Lacatation |
Not safe to be used |
| Sales Pack |
Pack of 30 tabs / box (5x6). |