Composition:
Amlodipine : 5 mg
Atenolol : 50 mg. |
| Mechanism of action |
AMLODIPINE is a dihydropyridine calcium channel-blocking agent
ATENOLOL is a long-acting cardioselective beta-adrenergic blocking
agent. The drug has no intrinsic sympathomimetic activity (ISA) or
membrane stabilizing properties.
|
| Indications |
Hypertension & Angina |
| Side effects |
Amlodipine
COMMON
Cardiovascular: Palpitations, Peripheral edema
Dermatologic: Flushing
Neurologic: Dizziness, Headache
Other: Fatigue
SERIOUS
Cardiovascular: Angina, Cardiac dysrhythmia (rare), Myocardial infarction
Atenolol
COMMON
Cardiovascular: Bradyarrhythmia, Cold extremities, Hypotension (4%)
Gastrointestinal: Diarrhea (3%), Nausea (3%)
Neurologic: Dizziness (13%), Fatigue (26%), Insomnia
Psychiatric: Depression
SERIOUS
Other: Lupus erythematosus |
| Precautions |
Amlodipine
Aortic stenosis
CHF
Exacerbation of angina during initiation of therapy, after dose increases,
or withdrawal of beta blocker therapy
Hypotension (initially or after dose increases)
Liver impairment
Persistent progressive dermatologic reactions
Atenolol
Anesthesia/surgery (myocardial depression)
Avoid abrupt withdrawal
Bronchospastic disease
Congestive heart failure
Diabetes mellitus
Hyperthyroidism/thyrotoxicosis
Patients receiving clonidine - discontinue atenolol several days prior to withdrawal of clonidine
Peripheral vascular disease
Pregnancy
Renal impairment
|
| Contraindications |
Amlodipine
History of hypersensitivity to Amlodipine/
Atenolol
Cardiogenic shock
Hypersensitivity to atenolol
Overt cardiac failure
Second and third degree AV block
Severe sinus bradycardia
|
| Pregnancy/ Lactation |
Not safe to be used |
| Sales Pack |
Amcard AT : Pack of 100 tabs/box (10 x 10) tabs. |
