Composition:
Fluconazole 400 mg dispersible tablets. |
| Mode of Action |
Fluconazole inhibits the fungal cytochrome P450 enzyme 14α demethylase. This inhibition prevents the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane, and subsequent accumulation of 14α-methyl sterols. Fluconazole is primarily fungistatic. |
| Indication |
In Pityriasis Versicolor |
| Dosage |
400 mg as a single dose to be repeated weekly for 2-3 weeks |
| Side Effects |
COMMON
Dermatologic: Pruritus, Rash
Gastrointestinal: Nausea, Vomiting
Hepatic: Increased liver enzymes
Neurologic: Headache
SERIOUS
Immunologic: Anaphylaxis (rare)
|
| Precautions |
Cardiac arrhythmias
Rarely hepatotoxicity.
|
| Contraindications |
Known hypersensitivity to Fluconazole or other azole antifungals. |
| Pregnancy/ Lactation |
Not safe to be used in these conditions. |
| Sales Pack |
AF-400 : pack of 10 tabs/box ( 2 x 5) |
